2022 Game Log
| Date | Location | Score | Winner |
|---|---|---|---|
| May Series — Wrigley Field | |||
| May 3 | Wrigley Field | Sox 3–1 | White Sox |
| May 4 | Wrigley Field | Sox 4–3 | White Sox Sox sweep the Wrigley series. |
| May Series — Guaranteed Rate Field | |||
| May 28 | Guaranteed Rate Field | Cubs 5–1 | Cubs Cubs salvage one on the South Side. |
| May 29 | Guaranteed Rate Field | Sox 5–4 (12) | White Sox Sox win in 12 innings to take the series 3-1. |
2022 Series Notes
Four games in 2022 due to MLB scheduling. The Sox took the series 3-1 and reclaimed the Crosstown Classic series lead. The Cubs were rebuilding, the Sox still had championship ambitions, though the season ultimately disappointed on the South Side.
The Sox swept the Wrigley series in June, then the Cubs salvaged one on the South Side in September before the Sox closed it out. South Side bragging rights for 2022.